Much research in the Lasko lab involves using Drosophila melanogaster to study the role of RNA-binding proteins and translational control in driving fundamental developmental processes. A long-term focus has been on vasa, which Prof. Lasko characterized as a postdoc, leading to the definition of the DEAD-box family of nucleic acid helicases (1,2). The Lasko lab has made many discoveries about how vasa functions in germ cell specification, embryonic patterning, and oogenesis, and how it regulates specific mRNAs (3-11). More recently, and in collaboration with Jean-Yves Roignant鈥檚 group (then in Mainz, now in Lausanne) we characterized Makorin-1 (12), which we had earlier found is also essential for embryonic patterning and germ cell specification (13). A makorin protein is implicated in human precocious puberty syndrome. In a long-term collaboration with Nahum Sonenberg鈥檚 group (成人VR视频 Biochemistry) we also have worked on cap binding proteins, linking eIF4E dysregulation to autism in a mouse model (14) discovering the role of an eIF4E inhibitor in embryonic patterning in flies (15,16), and elucidating the functions of two eIF4E cognates and an eIF4E binding protein in germ cell development (17-20). eIF4E has been linked to cancer as well as autism and clinical trials of several molecules that target it have been published.
We are dedicated to collaborative research. Our active partnerships include a collaboration with Nada Jabado (MUHC), Claudia Kleinman (Lady Davis Institute), Martin Hasselblatt (M眉nster), and Margret Shirinian (American University of Beirut) on using Drosophila to model effects of mutant histones implicated in pediatric high-grade gliomas (21,22). We also work with Ehab Abouheif (成人VR视频 Biology) on the role of the DNA damage response pathway in germline development and on the evolution and range of developmental mechanisms involved in oogenesis in Hymenoptera (23).
References
1. Lasko PF and Ashburner M (1988) Nature
2. Linder P, Lasko PF, Ashburner M, Leroy P, Nielsen PJ, Nishi K, Schnier J, and Slonimski PP (1989) Nature
3. Liang L, Diehl-Jones W, and Lasko P (1994) Development 120: 1201-1211.
4. Styhler S, Nakamura A, Swan A, Suter B, and Lasko P (1998) Development125: 1569-1578.
5. Carrera P, Johnstone O, Nakamura A, Casanova J, J盲ckle H, and Lasko P (2000) Mol. Cell
6. Liu N, Dansereau DA, and Lasko P (2003) Curr. Biol.
7. Johnstone O and Lasko P (2004) Development
8. Liu, N, Hong H, and Lasko P (2009) Genes Dev.
9. Kugler JM, Woo JS, Oh BH, and Lasko P (2010) Mol. Cell. Biol.
10. Dehghani M and Lasko P (2015) Biol. Open
11. Dehghani M and Lasko P (2016) Dev. Genes Evol.
12. Dold A, Han H, Liu N, Hildebrandt A, Br眉ggemann M, R眉ckl茅 C, H盲nel H, Busch A, Beli P, Zarnack K, K枚nig J, Roignant JY, and Lasko P(2020)PLoS Genet.
13. Liu N and Lasko P (2015) G3
14. Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, and Sonenberg N. (2013)Nature
15. Cho PF, Poulin F, Cho-Park YA, Cho-Park IB, Chicoine JD, Lasko P, and Sonenberg N (2005) Cell
16. Cho PF, Gamberi C, Cho-Park YA, Cho-Park IB, Lasko P, and Sonenberg N (2006) Curr. Biol.
17. Hern谩ndez G, Han H, Gandin V, Fabian L, Ferreira T, Zuberek J, Sonenberg N, Brill JA, and Lasko P(2012) Development
18. Hern谩ndez G, Miron M, Han H, Liu N, Magescas J, Tettweiler G, Frank F, Siddiqui N, Sonenberg N, and Lasko P (2013) Mol. Cell Biol.
19. Ghosh S and Lasko P (2015) PLoS One
20. Hern谩ndez G, Garc铆a A, Sonenberg N, and Lasko P (2020) J. Mol. Biol.
21. Berlandi J, Chaouch A, De Jay N, Tegeder I, Thiel K, Shirinian M, Kleinman CL, Jeibmann A, Lasko P, Jabado N, and Hasselblatt M. (2019) Neuro-Oncology
22. Chaouch A and Lasko P (2021) Fly
23. Ramsay C, Lasko P, and Abouheif E (2020) Evo-devo lessons from the reproductive division of labour in eusocial Hymenoptera. In: Evolutionary Developmental Biology鈥揂 Reference Guide (eds. Nu帽o de la Rosa, L. and M眉ller, G. B.),